Model:7501122964803
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Kinerase Facial & Body Moisturizer 40gr, N6-Furfuryladenine
USES AND APPLICATIONS: Kinerase ® is effective as monotherapy morning and evening, in the improvement and reversal of the cutaneous manifestations of photodamage, mild to moderate (types I and II of Gloau), or combined with other products or methods for the treatment of photoaging severe or advanced (types III and IV of Glogau).
In patients with early manifestations or even without them, it is recommended to use Kinerase ® as a preventative to slow the progression or occurrence of such events.
MECHANISM OF ACTION EFFECTS AND PHARMACOKINETICS: The N6-furfuryladenine is a substance originally identified in plants, but also found in humans. N6-furfuryladenine, is synthesized from deoxyribonucleic acid specifically from deoxyribose, which arises furfural radical, which is able to oxidize adenine set and thereby produce the active principle of KINERASE ®, made today considered one of the cellular mechanisms of self-healing.
Particularly in the skin, epidermal cells (keratinocytes) and skin (fibroblasts) undergo cumulative effects of solar radiation (UVB and UVA), which impact cellular chromophores such as DNA, proteins oxygen and cell membranes, as well as collagen and elastin. The effect on DNA photoproducts generated (thymine dimers) that give the appearance of a temporary paralysis of mitosis, after DNA repair causes a rapid mitosis. This causes rebound phenomenon cellular progressively wear, deteriorating the quality and reproductive regulation explaining the appearance of the manifestations of photodamage. Furthermore, UV rays, by acting on oxygen, producing free radicals such as superoxide, peroxides and hydroxyl radicals, potentially detrimental, as well as the appearance of multiple cytokines such as interleukins, tumor necrosis factor and other growth factors cell, to stop and control the violence but also exert effects that alter skin homeostasis.
Kinerase ®, on the N6-furfuryladenine counteracts these reactions, since cell factor and tissue repair itself, has 3 mechanisms of action. The first is to repair damaged DNA stimulates the activity of the enzyme photolyase, which is able to break the bonds that comprise thymine dimers, thereby preventing the cell from becoming stagnant and continue their life cycle. Secondly, KINERASE ® has a strong antioxidant effect because it stimulates the activity of superoxide dismutase enzyme, in combination with the copper ion, directly neutralizes free radicals. The third mechanism involves stimulating the rRNA and tRNA, increasing metabolism of proteins, which in the case of fibroblasts, can stabilize and normalize the synthesis of collagen and elastin.
It has been shown that the N6-furfuryladenine, in cultured fibroblasts, improves the quality and length of life cycle of the treated cells.
And N6-vehicle furfuryladenine KINERASE ® ensure optimum penetration of the active ingredient, which has been shown to reach effective concentrations in the three layers of the skin. Since furfuryladenine N6-deoxyribose is derived from DNA, it may be metabolized by natural degradation and may be eliminated or reused in other metabolic pathways.
Additionally, it has been shown that KINERASE ® significantly enhances skin hydration importantly reducing transcutaneous water loss, 12% at 12 weeks and 25% after 24 weeks of treatment, compared to the opposite effect of retinoic acid which increases loss water to 116%.
CONTRAINDICATIONS: None reported. However, it should be considered for patients with hypersensitivity to any component of the formula.
RESTRICTIONS OF USE DURING PREGNANCY AND LACTATION: Preclinical studies of mutagenicity and toxicity have shown no effect or risks, however, should be evaluated the usefulness of treatment during these stages.
ADVERSE REACTIONS: Because its active ingredient is not corrosive or erosive scrub as other treatments, its safety profile is a hallmark of the N6-furfuryladenine, since according to clinical studies in which we evaluated the prevalence of irritant reactions such as erythema, burning, dryness, itching and flaking, are reported in less than 1% of cases are mild and transient in nature, so it does not merit modify the treatment schedule, much less stopping.
Also, by its moisturizing reduces the likelihood of undesirable reactions.
DRUG INTERACTIONS AND OTHER GENDER: So far there have been documented. This possibility should be considered whenever you add another product or combination therapies are prescribed.
However, it is possible to associate Kinerase ® to other treatments, including scrubs, progressive or alpha hydroxy acids based intensive or other similar methods, with the understanding that the adverse reactions report patient may be attributable to these products.
CHANGES IN RESULTS OF LABORATORY TESTS: None reported.
PRECAUTIONS IN RELATION TO EFFECTS Carcinogenesis, Mutagenesis, Impairment of Fertility: Avoid applying formula cuts and abrasions of the skin, or in any area where there is continuity. Kinerase ® can be applied without restrictions on the periocular area without producing irritation or other adverse reactions.
Preclinical studies to assess the potential mutagenic, carcinogenic and acute and chronic toxicity Kinerase ® have shown no such effects.
KINERASE ® has also been subjected to allergenicity and irritability studies, demonstrating their safety same even with the skin patch method.
Because it is a component of natural, even present in human tissues, it is considered potentially risky.
ADMINISTRATION AND USE:
Kinerase ® is available in two formulations for topical application, dry skin cream, and lotion for normal or oily skin. Choose the most suitable for the skin type of the patient.
KINERASE ® dosed twice daily. At night after washing the skin that is to be treated, and in the morning after a bath or shower with soap. It can be applied as a foundation.
With fingertip, take a sufficient amount of cream or lotion and spreads over the entire surface to be treated, is the face, neck, shoulders, chest, back and hands. Once distributed, can rub lightly and gently. Must be quickly absorbed and disappear in a couple of minutes. Otherwise, you have been over the amount applied and should be less in the following applications pending determination of the amount in each case.
Photosensitizing KINERASE ® is not therefore be applied daily. If in the opinion of the physician, the patient's daily activities, it is considered necessary to recommend a sunscreen should be applied after the application of Kinerase ®.
Kinerase ® to complement intensive exfoliating procedures, dermabrasion and the like, can be used once the integrity of the skin has healed.
MANIFESTATIONS AND MANAGEMENT OF OVERDOSE OR ACCIDENTAL INGESTION overspray overdose poses no risk or reaction that requires special care. So far, not been reported, and in case of accidental ingestion, simply hold the patient under observation, since the ingredients of the formula are not toxic. Nausea and vomiting may manifest as diarrhea, which require no special handling beyond the recommended for these symptoms.
Drug Name: Kinerase
Comparable drug patent: Kinerase
Active substance: N6-furfuryladenine
Presentation: facial and body moisturizer
Concentration: 0.1%
Extended-release tablets: No
Laboratory: GROSSMAN
Box 40g tube
Made In: Mexico